Polyethylene glycol-coated sodium carbonate as a pharmaceutical excipient and compositions produced from the same
OwnerNipun DAVAR, Pauly KAVALAKATT +1inventors
InventorsNipun DAVAR, Pauly KAVALAKATT, Sangita GHOSH
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Abstract
Non-effervescent pharmaceutical compositions having at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the at least one carbonate particle are described. Compositions are also described where the compositions include a weakly basic therapeutic agent, a first pH-modifying agent having at least one particle of carbonate coated by a layer of polyethylene glycol, and a second pH-modifying agent. The weakly basic therapeutic agent could, but is not limited to, be zolpidem or scopolamine. Compositions including zolpidem and scopolamine are used to treat insomnia and depression, respectively.
Claims31
A pharmaceutical composition comprising:
- zolpidem;
- a first pH-modifying agent comprising at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the at least one carbonate particle;
- and
- a second pH-modifying agent selected from the group consisting of sodium bicarbonate, sodium phosphate dibasic, potassium phosphate dibasic, sodium citrate, potassium citrate, sodium acetate, and sodium tartrate.
A method for treating insomnia in a subject, comprising the steps of:
- administering to the subject a solid pharmaceutical composition comprising:
- zolpidem;
- a first pH-modifying agent comprising at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the carbonate particle;
- and
- a second pH-modifying agent,
- wherein the first and second pH-modifying agents are present in an amount sufficient to raise the pH of the subject's saliva to at least about 7.9.
A pharmaceutical composition comprising:
- scopolamine;
- a first pH-modifying agent comprising at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the at least one carbonate particle;
- and
- a second pH-modifying agent.
21-25. (canceled)
A method for treating depression in a subject, comprising the steps of:
- administering to the subject an orally dissolving film comprising:
- scopolamine;
- a first pH-modifying agent comprising a particle of carbonate coated by a layer of polyethylene glycol that substantially covers the carbonate particle;
- and
- a second pH-modifying agent,
- wherein the first and second pH-modifying agents are present in an amount sufficient to raise the pH of the subject's saliva to at least about 8.8.
27-33. (canceled)
A pharmaceutical composition comprising:
- a weakly basic therapeutic agent;
- a first pH-modifying agent comprising at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the at least one carbonate particle;
- and
- a second pH-modifying agent.
35-49. (canceled)
A layered composition comprising:
- carbonate and a pharmaceutically acceptable counter ion;
- and
- polyethylene glycol,
- wherein the carbonate is coated by a layer of polyethylene glycol that substantially covers the carbonate.
51-54. (canceled)
A layered composition comprising:
- a granule comprising carbonate and a pharmaceutically acceptable counter ion;
- and
- polyethylene glycol,
- wherein the polyethylene glycol is arranged in a layer that substantially covers the granule.
56-63. (canceled)
A layered composition comprising:
- a particle comprising carbonate and a pharmaceutically acceptable counter ion;
- and
- a layer of polyethylene glycol substantially surrounding the particle.
65-70. (canceled)
Dependencies are inferred from the claim text.