Method of making sustained release microparticles
AssigneeOakwood Laboratories, LLC
InventorsBagavathikanun Chithambara Thanoo, Gonto Johns, III, Byung Ho Woo
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Abstract
Various embodiments of a method of preparing sustained release microparticles are described. In one embodiment, the method includes the steps of forming a dispersed phase of an active agent in a polymer and combining the dispersed phase with a continuous phase to form a microparticle dispersion. The method further includes the step of adding a measured amount of a dilution composition to the microparticle dispersion. It has been found herein that the various embodiments for preparing sustained release microparticles using various amounts of the dilution composition alters the release rate of the sustained microparticle for the specific active agent.
Claims19
A method for forming sustained release microparticles comprising the steps of:
- forming a dispersed phase comprising an active agent dissolved with a polymer;
- mixing the dispersed phase with a continuous phase to form a microparticle dispersion comprising microparticles suspended in the continuous phase;
- and
- adding a measured amount of a dilution composition to the microparticle dispersion after the microparticles have been formed;
- wherein the amount of the dilution composition is sufficient to alter the release rate for the active agent.
A method for forming sustained release microparticles comprising the steps of:
- forming a dispersed phase comprising an active agent and a polymer;
- mixing the dispersed phase and a continuous phase to form a microparticle dispersion comprising microparticles suspended in the continuous phase;
- and
- adding a dilution composition to the microparticle dispersion to produce a sustained release microparticle having a release rate different than a release rate of an untreated sustained release microparticle;
- wherein the volume of the dilution composition is at least 50% of the volume of the continuous phase.
A method for controlling a release rate of a sustained release microparticle comprising the steps of:
- forming a dispersed phase comprising leuprolide and a polymer, wherein the leuprolide is dissolved in the polymer,
- mixing the dispersed phase with a continuous phase in a mixer to form a microparticle dispersion;
- adding a measured amount of a dilution composition to the microparticle dispersion after microparticles have been formed;
- and
- wherein the amount of a dilution composition is sufficient to alter the release rate for the specific active agent.
A sustained release composition with an altered release rate comprising:
- a dispersed phase comprising a specific active agent and a polymer, the dispersed phase combined with a continuous phase to form a microparticle dispersion, and the microparticle dispersion being exposed to a measured amount of a dilution composition after microparticles are formed;
- wherein the dilution composition is sufficient to dilute the continuous phase to alter the release rate of the specific agent.
Dependencies are inferred from the claim text.