Osmotic form for controlled release of active principles
AssigneeLibbs Farmaceutica Ltda.
InventorMiller Nunes de Freitas
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Abstract
The present invention refers to a tablet-shaped osmotic release system providing, in a controlled way, active principles which solubility depends on the pH of the medium, simultaneously providing appropriate solubilization throughout the gastrointestinal tract. The pharmaceutical osmotic release system comprises of a pharmaceutical layer, which contains at least one active principle in a solid solution, a propelling layer, which contains at least one osmopolymer and at least one osmoagent, a semipermeable coating involving both layers, and at least one orifice in the semipermeable coating at the side of the pharmaceutical layer.
Claims21
A pharmaceutical form for controlled release of one active principle, wherein a solubility of the pharmaceutical form depends on a low ph of a medium, the pharmaceutical form comprising:
- (a) a pharmaceutical layer comprising caverdilol c in a solid solution;
- (b) a propelling layer comprising at least one osmopolymer with a high molecular weight and optionally at least one osmoagent;
- (c) at least one semipermeable coating on the pharmaceutical layer and the propelling layer;
- and
- (d) at least one orifice at the semipermeable coating at a side of the pharmaceutical layer to release the active principle.
(canceled)
Dependencies are inferred from the claim text.