Controlled release pharmaceutical composition containing thiazides and angiotensin-ii-receptor blockers

A method for preparing a pharmaceutical composition, which comprises the following steps:

• (1) mixing or granulating an angiotensin-II-receptor blocker with pharmaceutically acceptable additives to obtain a mixture or granules, optionally compressing said granules or mixture into a tablet;
• (2) mixing particles or granules of a thiazide compound with at least one pharmaceutically acceptable additive to obtain a mixture, optionally dissolving or suspending said particles or granules with a film coating agent to obtain a coating solution;
• and
• (3) mixing the particles, granules or coating solution, obtained in the steps (1) and (2), with at least one pharmaceutically acceptable excipient, and
• (4) tableting, coating or filling the mixture.