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US 2010/0143450 A1Published application
DEVELOPMENT OF ASTHMA THERAPY WITH rAAV-mediated AMCase shRNA
AssigneeMingchi University of Technology
InventorsChao-Lin Liu, Ching-Jen Yang, Chia-Rui Shen
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Abstract
The invention provides small interfering RNA (siRNA) and their carriers that could treat asthma in mammalian through inhibiting acidic mammalian chitinase (AMCase) gene expression. The invention further provides a composition comprising siRNA of the present invention and a carrier. The invention also provides a method for treating asthma of a subject.
Claims11
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An isolated small interfering RNA (siRNA) polynucleotide having the nucleotide sequence set forth in SEQ ID NO:
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A composition comprising:
- an siRNA or a small hairpin RNA or short hairpin RNA (shRNA) targeted to a target transcript, or a nucleic acid that comprises a template for transcription of one or more RNA molecules that hybridize or self-hybridize to form an siRNA or shRNA targeted to a target transcript and the carrier which carrying them;
- wherein the target transcript encodes a protein named acidic mammalian chitinase (AMCase) involved in airway hyper responsiveness and inflammation in mammalian, and the carrier is Adeno-associated Vector (AAV) virus vectors or other viral vectors with small interfering RNA (siRNA) polynucleotide of SEQ ID NO:
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Dependencies are inferred from the claim text.