Peptides and peptide mimetics to treat pathologies associated with eye disease
OwnerGattadahalli M. Anantharamaiah, Alan M. Fogelman +2inventors
InventorsGattadahalli M. Anantharamaiah, Alan M. Fogelman, Mohamad Nayab, Martin Rudolf
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Abstract
This invention provides novel active agents (e.g. peptides, small organic molecules, amino acid pairs, etc.) peptides that ameliorate one or more symptoms of eye disease and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The agents are highly stable and readily administered via an oral route or via intraocular injection.
Claims26
A method for treating a subject with eye disease, the method comprising administering to the subject in need thereof an effective amount of one or more of the active agents described in Tables 2-18, and/or a small organic molecule as described herein in an amount sufficient to ameliorate one or more symptoms of said condition.
A method of ameliorating a symptom of eye disease, the method comprising administering to the subject to the subject in need thereof an effective amount of one or more of the active agents described in Tables 2-18, and/or a small organic molecule as described herein in an amount sufficient to ameliorate one or more symptoms of said condition.
The method of claim 13 wherein the symptom is selected from the group comprising accumulation of extracellular lipids in Bruch's membranes, accumulation of lipid rich debris, vision loss, formation of choriocapillaris, thickening of the Bruch's membrane, accumulation of neutral lipids in the Bruch's membrane, formation of a diffusion barrier between the retinal pigment epithelium and choriocapillaris, deposition of debris (basal linear deposits and drusen) between the basal membrane of the RPE, and the inner collagenous layer, accumulation of lipofuscin in the RPE cells, RPE atrophy, photoreceptor degeneration, choroidal neovascularization, as well as leakage, bleeding, scarring of the eye
The method of claim 13, wherein the eye disease is selected from the group comprising macular degeneration, age related maculopathy (ARM), age related macular degeneration (AMD) including both the dry and wet forms of age related macular degeneration, glaucoma, ocular hypertension, macular edema, retinal pigment epithelium detachments, coats disease, uveitis, sicca syndrome, hereditary diseases associated with increased extra-/intracellular lipid storage/accumulation, and juvenile macular degeneration,
A method of ameliorating a symptom of eye disease, the method comprising administering to the subject an effective amount of a peptide wherein said peptide:
- ranges in length from about 18 to 37 amino acids and comprises at least 3 alanines (A), 2 aspartates (D), 2 glutamates (E), 4 phenylalanines (F), 4 lysines (K), 1 valine (V), 1 tryptophan (W), 1 tyrosine (Y);
- wherein said peptide forms a class A amphipathic helix;
- comprises at least one “D” amino acid residue;
- and protects a phospholipid against oxidation by an oxidizing agent.
Use of an active agent described in Tables 2-18, and/or a small organic molecule as described herein in a treatment of macular degeneration.
A method for treating a subject with eye disease, the method comprising administering to the subject in need thereof an effective amount of one or more of the active agents described in Tables 2-18, and/or a small organic molecule as described herein in an amount sufficient to ameliorate one or more symptoms of said condition in combination with an anti-angiogenic therapy.
A method of ameliorating a symptom of eye disease, the method comprising administering to the subject to the subject in need thereof an effective amount of one or more of the active agents described in Tables 2-18, and/or a small organic molecule as described herein in an amount sufficient to ameliorate one or more symptoms of said condition in combination with an anti-angiogenic therapy.
Dependencies are inferred from the claim text.