Ul97 inhibitors for treatment of proliferative disorders
AssigneeThe UAB Research Foundation
InventorMark N. Prichard
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Abstract
Methods and compositions related to treating or preventing a proliferative disease in a subject comprising administering an inhibitor of a UL97 or a UL97 homolog to the subject are described.
Claims37
A method of treating or preventing a proliferative disease in a subject comprising the steps of:
- a) selecting a subject with a proliferative disease;
- and
- b) administering an inhibitor of a UL97 or a UL97 homolog to the subject.
An inhibitory peptide that binds (I) the LxCxE (SEQ ID NO:1) motif of a UL97 or a UL97 homolog, (ii) the LxCxD (SEQ ID NO:2) motif of a UL97 or a UL97 homolog, (iii) the LxCxE (SEQ ID NO:1) and LxCxD (SEQ ID NO:2) motifs of a UL 97 or a UL97 homolog, or (iv) the LxCxE (SEQ ID NO:1) and the DSSE (SEQ ID NO:13) motifs of a UL97 or a UL97 homolog.
(canceled)
(canceled)
(canceled)
A medical device comprising an implantable medical device and an inhibitor of a UL97 or a UL97 homolog.
A method of treating or preventing a neoplastic disease in a subject comprising the steps of:
- a) selecting a subject with a neoplastic disease;
- and
- b) administering an oncolytic herpesvirus to the subject, wherein the herpesvirus lacks a functional UL97 or a UL97 homolog.
A method of screening for agents that inhibit the activity of a UL97 or a UL97 homolog comprising the steps of:
- (a) providing a cell that expresses a UL97 or a UL97 homolog;
- (b) contacting the cell with a candidate agent to be tested;
- and
- (c) determining whether the candidate agent prevents the activation of Rb by the UL97 or the UL97 homolog.
A method of screening for agents that inhibit the activity of a UL97 or a UL97 homolog comprising the steps of:
- (a) providing a sample comprising a UL97 or a UL97 homolog and Rb;
- (b) contacting the sample with a candidate agent to be tested;
- and
- (c) determining whether the candidate agent prevents the activation of Rb by the UL97 or the UL97 homolog.
Dependencies are inferred from the claim text.