Biomolecules

A substrate having a biomolecule immobilized thereon, wherein the biomolecule is connected via an enzyme cleavable link to a blocking moiety such that cleavage of the link causes removal of the blocking moiety.

A method of enhancing cell adhesion to a substrate, the method comprising the steps of:

• i) immobilizing a biomolecule onto the substrate, the biomolecule comprising a cell recognition motif and being connected via an enzyme cleavable link to a blocking moiety such that cleavage of the link causes removal of the blocking moiety and subsequent activation of the biomolecule;
• and
• ii) exposing the biomolecule to an enzyme capable of cleaving the link.

A method of attenuating an inflammatory response in a subject following implantation of a medical device, the method comprising the step of immobilizing a biomolecule onto a surface of the device, wherein the biomolecule is connected via an enzyme cleavable link to a blocking moiety where cleavage of the link causes removal of the blocking moiety and activation of the biomolecule to an activated biomolecule, and wherein the activated biomolecule is an anti-inflammatory agent.