Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
AssigneeBBS-Bioactive Bone Substitutes Oy
InventorsElli Birr, Mari Ulmanen, Oili Hietala, Marja Juustila, Heli Korkala, Pekka Jalovaara
Life of this patent
Estimating the term…
Abstract
The present invention relates to reindeer bone formation inducing protein called bone morphogenetic protein (BMP), such as BMP-6, containing a heparin binding site and nucleotide molecules encoding the proteins and host cells expressing the proteins. The present invention relates also to the use of the bone morphogenetic protein for treating disorders related to bone and cartilage formation. The present invention further relates to osteogenic devices and pharmaceutical compositions containing the protein.
Claims26
An isolated bone morphogenetic protein (BMP) which is not BMP-2, characterized in that at the amino terminus it contains a heparin binding site containing the amino acid sequence AKEKQRKRGT (SEQ ID NO:
- 5).
14-15. (canceled)
A method for improving the expression of recombinant BMP protein in a bacterial host, characterized by adding a heparin binding site containing the amino acid sequence AKEKQRKRGT (SEQ ID NO:
- 5) to the amino terminus of said protein to be expressed.
A method for enhancing the biological activity of recombinant BMP protein, characterized by adding a heparin binding site containing the amino acid sequence AKEKQRKRGT (SEQ ID NO:
- 5) to the amino terminus of said protein.
Dependencies are inferred from the claim text.