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US 2010/0143408 A1Published application
Papillomavirus vaccines
AssigneeTransgene S.A.
InventorsMartine Baudin, Jean-Marc Balloul, Nathalie Silvestre
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AssigneeTransgene S.A.
InventorsMartine Baudin, Jean-Marc Balloul, Nathalie Silvestre
Estimating the term…
A nucleic acid molecule encoding at least one papillomavirus E2 polypeptide, or a vector, an infectious viral particle or a therapeutic composition thereof is formulated into a drug product useful for treating a patient suffering from a persistent papillomavirus infection caused by at least one papillomavirus; particular such vectors are nucleic acid molecules containing a first nucleotide sequence encoding a papillomavirus E1 polypeptide and a second nucleotide sequence encoding a papillomavirus E2 polypeptide wherein the 3′ portion of the first nucleotide which in the natural content is 100% identical to the 5′ portion of the second nucleotide is modified so as to exhibit a percentage of identity between said portions of at most 75%.
-49. (canceled)
A regime or regimen for the treatment of a host organism suffering from a persistent papillomavirus infection caused by at least one papillomavirus, comprising administering to such host organism, for such period of time as required to elicit the desired therapeutic response, a thus effective amount of a nucleic acid molecule encoding at least one papillomavirus E2 polypeptide or a vector or an infectious viral particle which comprises said nucleic acid molecule.
A vector comprising a nucleic acid molecule encoding a papillomavirus E1 polypeptide and a nucleic acid molecule encoding a papillomavirus E2 polypeptide wherein the 3′ portion of said E1-encoding nucleic acid molecule which in the natural context is 100% identical to the 5′ portion of said E2-encoding nucleic acid molecule is modified to exhibit a percentage of identity of less than 75% with said portion of said E2-encoding nucleic acid molecule.
A vector comprising a nucleic acid molecule encoding a papillomavirus E1 polypeptide and a nucleic acid molecule encoding a papillomavirus E2 polypeptide wherein said E1-encoding nucleic acid molecule and said E2-encoding nucleic acid molecule do not comprise a portion of 40 or more contiguous nucleotides exhibiting a percentage of identity of 75% or greater than 75%.
A vector comprising nucleic acid molecules encoding at least two papillomavirus E2 polypeptides wherein said E2-encoding nucleic acid molecules do not comprise a portion of 40 or more contiguous nucleotides exhibiting a percentage of identity of 75% or greater than 75%.
Dependencies are inferred from the claim text.