Novel influenza m2 vaccines
OwnerGale Smith, Rick Bright +1inventors
InventorsGale Smith, Rick Bright, D. Craig Wright
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Abstract
The present invention includes novel influenza antigenic formulations and vaccines that comprise influenza M2 peptide and VLPs comprising influenza M2 protein. The invention also includes methods of making and administering the novel antigenic formulation and vaccine. The invention also include methods of inducing immunity to ameliorate and/or prevent influenza infections in a subject.
Claims26
A method for the prevention, amelioration and/or treatment of influenza virus infection in a subject, comprising administering to said subject a M2 peptide or fragment thereof.
An antigenic formulation or vaccine comprising a M2 peptide or fragments thereof.
-20. (canceled)
A chimeric M2-M1 protein, wherein a M2 peptide fragment is fused at or near the N-terminus of the M1 protein.
A chimeric M2-HA protein, wherein the transmembrane and/or C-terminal domain of influenza HA is fused to the external domain of M2.
A chimeric M2-NA protein, wherein the transmembrane and/or C-terminal domain of influenza NA is fused to the external domain of M2.
-34. (canceled)
Dependencies are inferred from the claim text.