Hapten compounds and compositions and uses thereof
AssigneeBoard of Trustees of the University of Arkansas
InventorsS. Michael Owens, Melinda Gunnell, F. Ivy Carroll
Life of this patent
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Abstract
The invention generally relates to hapten compounds comprising either (+)methamphetamine or (+)amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+)methamphetamine, (+)amphetamine, or (+)MDMA.
Claims40
A compound comprising formula (I):
- wherein:
- R1 is selected from the group consisting of hydrogen and methyl;
- and
- L comprises a linker of at least 8 contiguous atoms, the atoms being selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl;
- provided, when L is less than 13 contiguous atoms, then the last atom of the linker opposite its point of attachment to the benzene ring does not form a carboxylic acid.
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A compound comprising formula (II):
- wherein:
- R1 is selected from the group consisting of hydrogen and methyl;
- and
- L comprises a linker of at least 11 contiguous atoms, the atoms being selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl.
-13. (canceled)
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A compound comprising formula (IV):
- wherein:
- R1 is selected from the group consisting of hydrogen and methyl;
- and
- L comprises a linker of at least 7 contiguous atoms, the atoms being selected from the group consisting of hydrogen, hydrocarbyl, and substituted hydrocarbyl.
-30. (canceled)
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A composition comprising a compound selected from the group consisting of a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), a compound of formula (V), a compound of formula (VI), a compound of formula (VII), a compound of formula (VIII), a compound of formula (IX), and a compound of formula (X).
-52. (canceled)
A method for generating specific antibodies for a compound selected from the group consisting of a compound of formula (I), a compound of formula (II), a compound of formula (III), a compound of formula (IV), a compound of formula (V), a compound of formula (VI), a compound of formula (VII), a compound of formula (VIII), a compound of formula (IX), and a compound of formula (X);
- the method comprising administering the compound to a subject.
-56. (canceled)
Dependencies are inferred from the claim text.