US 2010/0143387 A1 · MULTIMERIC CONJUGATE

Abstract

The present invention is directed to a multimeric agent and a multimeric conjugate formed from this multimeric agent and a biologically active agent. Said multimeric conjugates have a longer life time in vivo and an increased avidity compared to the unmodified biologically agent. The present invention is further directed to a pharmaceutical or diagnostic composition containing said conjugate as well as to a method of its production. The invention additionally provides the use of said conjugates for the detection, determination, separation and/or isolation of a specific binding partner and for the diagnosis, prophylaxis and treatment of diseases in which the specific binding partner is directly or indirectly involved.

Claims51

Dependent claims

A multimeric agent of the following formula:

Z—(X—Pol-Y)n
wherein
Z is a homo-multifunctional hydrocarbon with 1 to 50 carbon atoms which optionally contains heteroatoms;
X is a hydrocarbon linker with 1-15 carbon atoms, which optionally contains heteroatoms and which is capable of forming a stable linkage between Z and Pol;
Pol is a water soluble, non-toxic polymer,
Y is a coupling agent capable of coupling to a biologically active agent, and
n is an integer from 4-20.

4 more elements

Dependencies are inferred from the claim text.

Multimeric conjugate

Life of this patent

Multimeric conjugate

Life of this patent

Abstract

Claims51