Modulation of rhamm (cd168) for selective adipose tissue development
AssigneeThe Regents of the University of California
InventorsEva A. Turley, Mina J. Bissell
Life of this patent
Estimating the term…
Abstract
Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.
Claims19
1-22. (canceled)
A method of modulating mesenchymal stem cell differentiation, said method comprising:
- promoting differentiation of a myofibroblastic lineage by contacting said stem cells with a compound that enhances Rhamm function;
- or
- promoting differentiation of an adipocyte lineage by contacting said stem cells with a compound that reduces or inhibits Rhamm function.
A composition for promoting wound repair in a wound but decreasing the formation of scarred tissue, said composition comprising an anti-Rhamm compound in a carrier suitable for application to a wound or surgical site.
A kit comprising an anti-Rhamm compound in a predetermined concentration, a carrier for delivery of a therapeutic amount to a patient, and instructions for administration to said patient.
Dependencies are inferred from the claim text.