Products for prophylaxis and/or treatment of viral diseases and methods of making and using same
OwnerOrgad Laub, Israel Nur +1inventors
InventorsOrgad Laub, Israel Nur, Nadav Orr
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Abstract
The invention relates to an immunoglobulin composition suitable for prophylaxis and/or treatment of a viral mediated disease, disorder or condition and to methods of its preparation. In one embodiment, the invention provides a potent intravenous immunoglobulin composition useful for the treatment or prevention of a West Nile virus mediated disease, disorder or condition.
Claims19
A method for the preparation of an immunoglobulin composition comprising a high level of neutralizing antibody specific for a pathogenic virus causing a new emerging disease, disorder or condition in a target geographic area, the method comprising:
- screening blood or blood fractions of a plurality of donors from a population of a geographic area endemic to the virus, in which population the percentage of seropositive donors to said virus is not more than 25%, in the range of 1-15%, or in the range of 8-13%;
- and
- isolating and pooling all blood or blood fractions of donors that are positive for antibody specific to the pathogenic virus strain.
A method for the preparation of an immunoglobulin composition comprising a high level of anti-West Nile Virus (WNV) neutralizing antibody for treating or preventing a disease, disorder or condition caused by WNV in a target geographic area, the method comprising:
- screening blood or blood fractions of a plurality of donors from a population of a geographic area endemic to the virus, in which population the percentage of seropositive donors to said virus is not more than 25%, in the range of 1-15%, or in the range of 8-13%;
- and
- isolating and pooling all blood or blood fractions of donors that are positive for antibody against WNV.
A potent immunoglobulin composition comprising high levels of antibodies specific for WNV of a target geographic area, wherein said composition comprises immunoglobulin from pooled blood or blood fractions of donors that are all positives for antibody against WNV, wherein said donors are from a population of a geographical area endemic to WNV, and wherein said composition has a high level of antibody against the WNV of the target geographical area that is more than 5 times, 10 times, 11 times, or about 20 times higher than the level of anti WNV antibody of immunoglobulin from a regular pool of blood or blood fractions of donors of the geographic area endemic to the virus.
A method for treating or preventing a WNV associated disease, disorder or condition comprising administering to a subject in need a therapeutically effective amount of an immunoglobulin composition according to 11.
A method for treating or preventing a WNV associated disease, disorder or condition which requires administration of unreachable excessive amount and/or volume of IVIG from a regular pool of donors of the geographic area endemic to the virus, the method comprising administering to a subject in need a therapeutically effective amount of an immunoglobulin composition 11.
An efficient method for screening and selecting blood or blood fractions comprising a high level of neutralizing antibody specific for a pathogenic virus causing a disease, disorder or condition from numerous blood or blood fractions samples comprising the steps of:
- screening, using an ELISA assay, blood or blood fraction samples obtained from donors of a population from a geographic area endemic to the virus, in which population the percentage of seropositive donors to said virus is not more than 25%, in the range of 1-15%, or in the range of 8-13%;
- and selecting blood or blood fraction of donors that are positive for antibody specific for said pathogenic virus.
Dependencies are inferred from the claim text.