Chimeric Antibodies, Compositions and Methods for Treating Cocaine-Related Disorders
AssigneeVybion, Inc.
InventorsLee A. Henderson, John D. Noti, Wallace R. Fish, Brian Miller
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Abstract
The invention relates to antibodies, including chimeric monoclonal antibodies, and fragments thereof, that bind to cocaine. The invention also relates to the use of these or any anti-cocaine antibodies, derivatives or variants in the prevention or treatment of cocaine-related disorders and in the amelioration of one or more symptoms associated with a cocaine-related disorder.
Claims18
An isolated monoclonal antibody or fragment thereof that binds cocaine, wherein said antibody or fragment thereof comprises a heavy chain a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 7, a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 8, a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 9, and a light chain comprising the light chain constant region of SEQ ID NO:
- 4, a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 10, a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 11, and a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 12.
An isolated monoclonal antibody or fragment thereof that binds cocaine, wherein said antibody or fragment thereof comprises the heavy chain sequence of SEQ ID NO:
- 2 and a light chain sequence selected from the group consisting of SEQ ID NOs:
- 6 and 14.
An isolated monoclonal antibody or fragment thereof that binds cocaine, wherein said antibody or fragment thereof comprises the heavy chain sequence of SEQ ID NO:
- 2 and the light chain sequence of SEQ ID NO:
- 14.
A method of alleviating a symptom of a cocaine-related disorder, the method comprising administering an antibody or fragment thereof that binds cocaine to a subject in need thereof in an amount sufficient to alleviate the symptom of the cocaine-related disorder in the subject, wherein the antibody or fragment thereof comprises a heavy chain a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 7, a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 8, a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 9, and a light chain comprising the light chain constant region of SEQ ID NO:
- 4, a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 10, a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 11, and a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 12.
An Fab antibody fragment comprising at least two copies of a CDR3 region selected from a VH CDR3 region that includes at least the amino acid sequence of SEQ ID NO:
- 9, a VL CDR3 region includes at least the amino acid sequence of SEQ ID NO:
- 12, and combinations thereof, wherein said Fab fragment specifically binds cocaine.
Dependencies are inferred from the claim text.