Human vascular endothelial growth factor 2
AssigneeHuman Genome Sciences, Inc.
InventorsCraig Rosen, Jing-Shan Hu, Liang Cao
Life of this patent
Estimating the term…
Abstract
Disclosed is a human VEGF2 polypeptide and DNA(RNA) encoding such VEGF2 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist against such polypeptide. Also disclosed is a method of using such polypeptide for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antagonists to inhibit tumor growth, inflammation and to treat diabetic retinopathy, rheumatoid arthritis and psoriasis. Diagnostic methods for detecting mutations in the VEGF2 coding sequence and alterations in the concentration of VEGF2 protein in a sample derived from a host are also disclosed.
Claims25
1-28. (canceled)
An isolated antibody or fragment thereof that specifically binds to a polypeptide selected from the group consisting of:
- (a) a polypeptide consisting of amino acid residues −46 to +23 of SEQ ID NO:
- 2;
- (b) a polypeptide consisting of amino acid residues −46 to −1 of SEQ ID NO:
- 2;
- (c) a polypeptide consisting of amino acid residues −46 to −23 of SEQ ID NO:
- 2;
- (d) a polypeptide consisting of amino acid residues −23 to +23 of SEQ ID NO:
- 2;
- (e) a polypeptide consisting of amino acid residues −23 to −1 of SEQ ID NO:
- 2;
- and
- (f) a polypeptide consisting of amino acid residues −1 to +23 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.