Therapeutic and diagnostic anti-hsp70 antibodies
AssigneeMultimmune GmbH
InventorGabriele Multhoff
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Abstract
Methods and compositions for the detection, prevention and treatment of infectious diseases, primary and metastatic neoplastic diseases, including, but not limited to human sarcomas and carcinomas are described. In particular, specific antibodies are provided, which are capable of binding an epitope of Hsp70 that is extracellularly localized on diseased tissue and cells, in particular on tumor cells and infected cells.
Claims13
A method of treating a tumor or modulating the immune response in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an antibody or antigen-binding fragment thereof that binds to an extracellular localized epitope of Hsp70 on tumor cells.
Dependencies are inferred from the claim text.