Complement inhibition for improved nerve regeneration
AssigneeAcademisch Ziekenhuis bij de Universiteit van Amsterdam
InventorsFrank Baas, Valeria Ramaglia
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Abstract
The present invention relates to methods and medicaments used for treating conditions that require axonal regeneration, e.g. in mammals affected by injury or disease of the central or peripheral nervous system. The medicaments used in these methods facilitate axonal regeneration by inhibition of the complement system. Conditions requiring axonal regeneration that may be treated in accordance with the invention include physical injuries as well as neurodegenerative disorders of the peripheral or central nervous system.
Claims41
1-14. (canceled)
A method of treating a subject having a condition requiring axonal regeneration comprising administering to the subject a therapeutically effective amount of a medicament comprising an inhibitor of a mammalian complement system.
(canceled)
A method of treating a subject having a condition requiring axonal regeneration comprising administering to the subject a therapeutically effective amount of plasma-derived or transgenic inhibitor of mammalian complement system C1 (C1INH) sufficient to treat the subject, wherein the condition is a traumatic injury to the CNS.
A method of treating a subject having a condition requiring axonal regeneration comprising administering to the subject a therapeutically effective amount of plasma-derived or transgenic inhibitor of mammalian complement system C1 (C1INH) sufficient to treat the subject, wherein the condition is a traumatic injury to the PNS.
Dependencies are inferred from the claim text.