Method of treating diabetes
AssigneeGarvan Institute of Medical Research C/-St. Vincent's Hospital
InventorJenny Gunton
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Abstract
The present invention relates to a method for treating a subject having or at risk of a diabetes-related disorder. In a preferred embodiment, the method involves increasing the level or activity of Hypoxia Induced Factor 1 (HIF-1 α) in pancreatic-β-cells or insulin-sensitive tissues in the subject by administering to the subject an inhibitor of a protein that decreases the level or activity of HIF-1α. The present invention also relates to a method of transplanting pancreatic islet cells in a subject.
Claims23
A method for treating a subject having or at risk of a diabetes-related disorder, the method comprising increasing the level or activity of Hypoxia Induced Factor 1α (HIF-1α) in pancreatic β-cells or insulin-sensitive tissues in the subject by administering to the subject an inhibitor of a protein that decreases the level or activity of HIF-1α.
A method of transplanting pancreatic islet cells in a subject, the method comprising:
- (i) administering islet cells to the subject;
- and
- (ii) increasing the level or activity of HIF-1α in the islet cells by administering to the subject an inhibitor of a protein that decreases the level or activity of HIF-1α.
Dependencies are inferred from the claim text.