Method for mixing powders
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsTorsten Schultz-Fademrecht, Sandra Zimontkowski, Patrick Garidel, Hans-Joachim Kern, Klaus-Juergen Steffens
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Abstract
The invention relates to a method for preparing powder mixtures, one component consisting of spray-dried powder. The invention also relates to a method for coating spray-dried particles with nanoscale particles, a method for mixing spray-dried powder with microscale particles and a method for covering carrier substances with spray-dried particles.
Claims37
A method of mixing spray-dried powder with nanoparticles, microscale particles and/or with carriers, the comprising mixing the spray-dried powder with nanoparticles, microscale particles and/or with carriers in a spray dryer.
A method of mixing powders, comprising the following steps:
- a. spraying/atomising a spray solution containing one or more substances that are to be sprayed, as well as optionally one or more excipients, into a compartment,
- b. drying the resulting drops in the same compartment as in step (a),
- c. introducing one or more other powders containing e.g. carriers or nanoparticles into the same compartment as in step (b) under conditions in which a mixture is formed and
- d. collecting the particles formed.
(canceled)
29-31. (canceled)
A powder mixture, comprising a spray-dried protein content chosen from
- more than 1% (w/w),
- more than 30% (w/w),
- more than 35% (w/w),
- more than 40% (w/w),
- more than 45% (w/w),
- more than 50% (w/w),
- more than 55% (w/w),
- more than 60% (w/w),
- more than 65% (w/w),
- more than 70% (w/w),
- more than 80% (w/w) and
- more than 90% (w/w),
- and further comprising at least one nanoparticle or a carrier, the powder mixture having a fine particle fraction chosen from
- more than 15% (w/w), more than 25% (w/w), more than 35% (w/w), more than 45% (w/w), more than 55% (w/w) and more than 65% (w/w).
Dependencies are inferred from the claim text.