Methods of treating disorders associated with fat storage
AssigneesUnversidadDe Salamanca (O.T.R.I.), Consejo Superior de Investigaciones Cientificas
InventorsIsidro Sanchez-Garcia, Pedro A. Perez-Mancera
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Abstract
The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
Claims47
A method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
The method according to any preceding claim comprising administering the SLUG protein, a modified form of the SLUG protein or a functional equivalent of the SLUG protein to the mammal.
Use of the SLUG protein, a modified form of the SLUG protein or a functional equivalent of the SLUG protein for treating or preventing a disorder associated with increased or decreased fat storage in a mammal.
Use of a compound that modulates the activity of the SLUG protein, or modulates transcription and/or translation of the SLUG gene for treating or preventing a disorder associated with increased or decreased fat storage in a mammal.
A method for screening for a compound that modulates the activity of the SLUG protein or a functional equivalent of the SLUG protein or modulates the level of transcription or translation from the SLUG gene, comprising administering a candidate compound to a test non-human mammal and monitoring the effect on fat storage in the test non-human mammal.
A method for screening for a compound that modulates the level of transcription or translation from the SLUG gene, or modulates the activity of the SLUG protein or a derivative of the SLUG protein, comprising contacting a cell with a candidate compound and monitoring the amount of lipid accumulation in the cell.
Dependencies are inferred from the claim text.