Modified phosphatases
AssigneeAM-Pharma B.V.
InventorsMarkwin Paul Velders, Luigi Johannes Cornelius Jonk, Willem Raaben, Marty Bernardus Fransiscus Wulferink
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Abstract
The invention relates to phosphatases and more in specific to (genetically) modified phosphatases, pharmaceutical compositions comprising (genetically) modified phosphatases and the use of (genetically) modified phosphatases for treating or curing for example sepsis, inflammatory bowel disease or other inflammatory diseases, or renal failure. The invention further relates to a method for producing phosphatases.
Claims32
1-35. (canceled)
An alkaline phosphatase, wherein the alkaline phosphatase is isolated or recombinant and comprises:
- a crown domain, and
- a catalytic domain,
- wherein the crown domain and the catalytic domain are obtained from different alkaline phosphatases.
An isolated or recombinant phosphatase comprising a mutation in the vicinity of a catalytic residue and/or in a metal ion-coordinating phosphate-binding pocket, wherein the mutation is a mutation as depicted in Table 4, 5, or 6.
Dependencies are inferred from the claim text.