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AssigneeRutgers, The State University of New Jersey
InventorsWilliam G. Johnson, Edward S. Stenroos
Estimating the term…
The present invention provides novel markers and assays for autism based on the association of GSTP1 with prevalence for having a child or children with autism or autistic disease. The invention relates to the use and application of GSTP1 as a susceptibility marker and teratogenic allele for autism. In particular the genotype of GSTP1 at amino acids 105 and 114, corresponding to nucleotides 313 and 341 are determined. GSTP1 may be combined with other markers in methods and assays for monitoring, managing, diagnosis, prenatal diagnosis, and assessment of autism. In addition, the present invention discloses a novel method for identifying individuals who are genetically susceptible to have offspring with autism wherein the genotype of GSTP1, alone or in combination with other genetic markers or other indicators of oxidative stress, is determined.
A method for determining the susceptibility of an individual to have offspring that is at risk of developing autism comprising:
An assay for determining susceptibility to having an offspring with autism in a subject which comprises
A method of estimating the susceptibility of an individual to have offspring that develop a developmental disorder comprising:
A test kit for assessing susceptibility to autism in an offspring of a pregnant woman, comprising nucleic acid probes or primers for determining the GSTP1 genotype of said pregnant woman, such that GSTP1 genotype is determined and the susceptibility to autism is assessed in said offspring.
A method for modulating susceptibility to autism in a fetus or offspring in a pregnant woman comprising determining the GSTP1 genotype of said pregnant woman, wherein upon determination of a GSTP1 genotype resulting in altered enzyme activity or substrate specificity of GSTP1 in said pregnant woman, the oxidative stress of the pregnant woman is monitored during pregnancy and modulated by antioxidant and/or oxidative stress therapy or management.
Dependencies are inferred from the claim text.