Treatment of hiv and aids using probiotic lactobacillus reuteri
OwnerJames Allen Lemkeinventor
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Abstract
A method for treating or preventing a Human Immunodeficiency Virus (HIV) infection, or treating or preventing Acquired Human Immunodeficiency Syndrome (AIDS), in a subject in need thereof, is disclosed. The method involves colonizing a genetically modified probiotic Lactobacillus reuteri RC-14 in the gastrointestinal tract of a subject, wherein the probiotic is able to secrete two or more fusion inhibitors that decrease or prevent HIV production and CD4+T cell depletion in the gastrointestinal tract.
Claims14
A method for treating or preventing a Human Immunodeficiency Virus (HIV) infection, or treating or preventing Acquired Human Immunodeficiency Syndrome (AIDS), in a subject in need thereof, comprising:
- a) engineering Lactobacillus reuteri RC-14 to secrete at least two fusion inhibitors;
- b) colonizing the engineered probiotic Lactobacillus reuteri RC-14 in the gastrointestinal tract of the subject;
- c) secreting the fusion inhibitors in the gastrointestinal tract;
- and
- d) decreasing or preventing HIV production and CD4+T cell depletion in the gastrointestinal tract because of the presence of the two or more fusion inhibitors, wherein the two or more fusion inhibitors are selected from the group consisting of PRO 542, MIP-1β and T-1249.
A method of reducing or preventing HIV replication in a CD4+T cell in gut associated lymphatic tissue (GALT) of a gastrointestinal tract, comprising interfering with the binding, fusion or entry of HIV viron into the CD4+T cell in GALT by two or more fusion inhibitors secreted by a genetically modified probiotic Lactobacillus reuteri RC-14.
A method of reducing or preventing depletion of CD4+T cells in GALT of a gastrointestinal tract caused by initial HIV infection, comprising reducing or preventing HIV replication in the GALT by presence of two or more fusion inhibitors secreted by a genetically modified probiotic Lactobacillus reuteri RC-14.
Dependencies are inferred from the claim text.