Compositions for aerosolization of highly conductive solutions
AssigneeBattelle Memorial Institute
InventorsMichael D. Triplett, Bruce D. McVeety, Christopher Rulison
Life of this patent
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Abstract
Compositions for aerosolization of conductive solutions (preferably highly conductive solutions) by way of electrostatic or electrohydrodynamic spraying are provided. Methods for making and using these compositions and electrostatic and electrohydrodynamic aerosol generators containing these compositions are also provided.
Claims39
A highly conductive liquid composition capable of aerosolization using an EHD aerosol generating device, wherein said highly conductive liquid composition has a surface viscoelastic modulus of from about 0.5 mN/m to about 10 mN/m, a phase angle of from about 10 degrees to about 50 degrees, and a conductivity of from about 5.0 μSiemens/cm to about 1000 μSiemens/cm;
- wherein said composition comprises:
- (i) an active agent;
- (ii) a liquid carrier vehicle which is ethanol;
- (iii) a material for adjusting surface rheological properties;
- and
- (iv) optionally a formulation additive or mixtures thereof;
- wherein said active agent is dissolved or suspended in said liquid carrier vehicle.
The highly conductive liquid composition according to claim 6, wherein the conductivity of said liquid composition ranges from about 10 μSiemens/cm to about 400 μSiemens/cm.
12-26. (canceled)
A highly conductive liquid composition for direct delivery of an active agent to a target surface wherein said highly conductive liquid composition is capable of aerosolization using an electrohydrodynamic aerosolization means, wherein said liquid composition has a surface viscoelastic modulus of from about 0.5 mN/m to about 10 mN/m, a phase angle of from about 10 degrees to about 50 degrees, and a conductivity of from about 12.5 μSiemens/cm to about 400 μSiemens/cm;
- wherein said composition comprises:
- (i) an active agent;
- (ii) a liquid carrier vehicle which is ethanol;
- (iii) a material for adjusting surface rheological properties;
- and
- (iv) a formulation additive or mixtures thereof;
- wherein said active agent is dissolved or suspended in said liquid carrier vehicle.
(canceled)
(canceled)
The aerosol formed when a highly conductive liquid composition is aerosolized according to claim 14, wherein said aerosol has an aerosol particle diameter of from about 1.0 μm to about 5.0 μm.
A method for delivering an active agent to the respiratory tract of a patient in need of treatment comprising the steps of:
- (a) preparing a highly conductive liquid composition wherein said composition comprises:
- (i) a pharmaceutically active agent;
- (ii) a liquid carrier vehicle which is ethanol;
- (iii) a material for adjusting surface rheological properties;
- and
- (iv) optionally a formulation additive and mixtures thereof
- (b) dissolving or suspending an effective amount of said pharmaceutically active agent in said liquid carrier vehicle to produce a solution or suspension;
- (c) producing an aerosol of said solution or suspension using an electrohydrodynamic aerosolization means;
- and
- (d) administering said aerosol to the pulmonary tract of said patient via inhalation of said aerosol;
- wherein said highly conductive liquid composition has a surface viscoelastic modulus of from about 0.5 mN/m to about 10 mN/m;
- a phase angle of from about 10 degrees to about 50 degrees;
- and a conductivity of from about 5.0 μSiemens/cm to about 1000 μSiemens/cm;
- and wherein the particle size of said aerosol is from about 1.0 microns to about 30 microns in diameter.
Dependencies are inferred from the claim text.