Compounds and amyloid probes thereof for therapeutic and imaging uses

An amyloid binding compound of the formula

• wherein
• R1 is H, F, Cl, Br, I, NO2, CN, CF3, alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR6, NR5R6 or R6,
• R2 is H, F, Cl, Br, I, NO2, CN, CF3, alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR6, NR5R6 or R6,
• R3 is H, F, Cl, Br, I, NO2, CN, CF3, alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR6, NR5R6 or R6,
• R4 is H, F, Cl, Br, I, NO2, CN, CF3, alkyl, alkenyl, alkynyl, alkoxy, monoalkylamine, dialkylamine, hydroxyalkyl, haloalkyl, alkylthio, alkylsulfonyl, aryl, heterocycles, heteroaryl, aralkyl, carboxy, esterified carboxy, amidate carboxy, OR6, NR5R6 or R6,
• R5 is CnH2n+1 or —CH2—CH═CH—I and R6 is CnH2n+1, —[CH2—CH2—O]m—R5, where n and m are independently 0, 1, 2, 3, 4, 5, 6 or 7,
• Y is CH or N, and
• Z is CH or N.