Uses of monoclonal antibody 8h9
AssigneeSloan-Kettering Institute for Cancer Research
InventorNai-Kong V. Cheung
Life of this patent
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Abstract
The present invention discloses monoclonal antibody 8H9 which binds to the 4Ig domain isoform of the human B7-homolog 3, 4Ig-B7H3. The present invention provides a method of improving the prognosis or prolonging the survival of a subject bearing tumor cells, the method comprises administering to the subject a composition comprising an effective amount of an agent capable of binding to an antigen recognized by monoclonal antibody 8H9.
Claims19
1-44. (canceled)
A method of improving the prognosis or prolonging the survival of a subject bearing a tumor, comprising administering to the subject a composition comprising an effective amount of an agent capable of binding to an antigen recognized by monoclonal antibody 8H9.
A method of screening for antibodies that have the same or similar binding specificity as monoclonal antibody 8H9, comprising the step of contacting candidate antibodies with a polypeptide comprising the sequence of SEQ ID NO.15, or a fragment thereof, wherein antibodies that bind to the polypeptide are antibodies that have the same or similar binding specificity as monoclonal antibody 8H9.
A method of upregulating anti-metastatic immune response in NK or T cells comprising the steps of blocking B7H3 receptors present on NK or T cells with an appropriate agent.
Dependencies are inferred from the claim text.