Apparatus and Method for Filtration to Enhance the Detection of Peaks
OwnerChulso Moon, Atsushi Takanoinventors
Life of this patent
Estimating the term…
Abstract
Filters and methods for enhancing the identification of peaks in mass spectroscopy data are disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data. The methods of the present invention may be used for enhancing relevant peaks in mass spectra data for use in identifying and diagnosing diseases or for predicting responses to particular disease treatments.
Claims74
A method for determining the probability of disease, comprising:
- filtering a biological fluid through a hole array filter,
- generating mass spectra data from the filtered biological fluid;
- and
- comparing the mass spectra data with a database.
A method of predicting response to disease treatment comprising:
- generating a first set of mass spectra data from a first set of samples from a population that responds to a treatment of a disease A after filtration of the first set of samples through a hole array filter;
- generating a second set of mass spectra data from a second set of samples from a population that does not respond to the same treatment of disease A after filtration of the second set of samples through a hole array filter;
- and
- comparing corresponding peaks in first and second sets of mass spectra data, wherein a difference in corresponding peaks indicates that the peaks represent at least one marker indicating the likelihood of response to the treatment of disease A;
- wherein upon identifying the at least one marker, using the at least one marker to predict the likelihood of response to the treatment of disease.
A method of enhancing the identification of peaks in a mass spectrometric method comprising:
- filtering a sample through a hole array filter, and
- generating mass spectra data from the filtered sample.
A method of increasing sensitivity and specificity in disease detection comprising:
- generating a first set of mass spectra data from a first set of biological fluid samples from a population with disease A after filtration of the first set of biological fluid samples through a hole array filter;
- generating a second set of mass spectra data from a second set of biological fluid samples from a population without disease A after filtration of the second set of biological fluid samples through a hole array filter, and
- comparing the first and second sets of mass spectra data, wherein a difference between corresponding peaks in the first and second sets of mass spectra data indicates at least one disease A negative marker.
An apparatus for filtering biological fluid to predict response to disease treatment, comprising:
- at least one hole array filter;
- wherein:
- a first set of samples from a population that respond to a treatment of a disease A is filtered through one of said at least one hole array filter;
- a first set of mass spectra data is generated from the first set of samples after filtering through one of said at least one hole array filter,
- a second set of samples from a population that does not respond to the same treatment of disease A is filtered through one of said at least one hole array filter;
- a second set of mass spectra data is generated from the second set of samples after filtering through one of said at least one hole array filter, and
- corresponding peaks in the first and second sets of mass spectra data are compared, wherein a difference in corresponding peaks indicates that the peaks represent at least one marker indicating the likelihood of response to the treatment of disease A.
An apparatus for filtering biological fluid to detect disease by measuring mass spectra data of filtered biological fluid, comprising:
- at least one hole array filter;
- wherein:
- a first set of biological fluid samples from a population with disease A are filtered through one of said at least one hole array filter;
- a first Set of mass spectra data is generated from the first set of biological fluid samples after filtering through one of said at least one hole array filter,
- a second set of biological fluid samples from a population without disease A are filtered through one of said at least one hole array filter;
- a second set of mass spectra data is generated from the second set of biological fluid samples after filtering through one of said at least one hole array filter;
- and
- the first and second sets of mass spectra data are compared, wherein a difference between corresponding peaks in the first and second sets of mass spectra data indicates at least one disease A negative marker.
An apparatus for filtering biological fluid to enhance the identification of peaks in a mass spectrometric method, comprising:
- a hole array filter,
- wherein:
- a biological fluid sample is filtered through said hole array filter;
- and
- mass spectra data is generated from the filtered biological fluid sample.
Dependencies are inferred from the claim text.