Humanized anti-il-6 antibodies
AssigneeBioAtla, Inc.
InventorsGerhard Frey, Hwai Wen Chang, Jay Short
Life of this patent
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Abstract
The present invention relates to novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
Claims38
An isolated antibody or antibody fragment that binds to human IL-6, comprising a heavy chain variable region having the amino acid sequence of SEQ ID NO:
- 3, 7, 11, 15, 19, 23, 27, 31, 134, 140, 141, 144, 147, 149, 152, 153 or 156;
- a light chain variable region having the amino acid sequence of SEQ ID NO:
- 1, 5, 9, 13, 17, 21, 25, 29, 68, 71, 72, 75, 76, 80 or 88;
- and a constant region derived from one or more human antibodies.
An isolated antibody or antibody fragment that binds to human IL-6, comprising a heavy chain and light chain complementarity determining regions (CDRs) derived from the variable regions from one or more of BA399, BA436, BA802, BA808, BA840, BA848, BA890 and BA939, and a constant region derived from one or more human antibodies.
Dependencies are inferred from the claim text.