Transgenic pig as a model of alzheimer's disease

A genetically modified pig as a model for studying Alzheimer's disease, wherein the modified pig expresses at least one phenotype associated with said disease, and/or

• a modified pig comprising at least one modified gene or combination of modified genes selected from
• i) human APP gene or part thereof,
• ii) human PS1 gene or part thereof,
• iii) porcine APP gene or part thereof,
• iv) porcine PS1 gene or part thereof,
• v) APP gene or part thereof and at least one modified PS1 gene or part thereof,
• vi) human APP gene or part thereof comprising a Swedish mutation,
• vii) human APP gene or part thereof being the APPsw695 gene,
• viii) human PS1 gene or part thereof comprising a mutation encoding a PS1 protein harbouring a Pro117Leu mutation,
• ix) human APP gene or part thereof comprising a Swedish mutation and at least one modified PS1 gene or part thereof comprising a mutation encoding a PS1 protein harbouring a Pro117Leu mutation, and
• x) human APP gene or part thereof being the APPsw695 gene and at least one modified PS1 gene or part thereof comprising a mutation encoding a PS1 protein harbouring a Pro117Leu mutation,
• or a transcriptional and/or translational product or part thereof.