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AssigneeAarhus Universitet
InventorsJacob Fog Bentzon, Charlotte Brandt Sørensen, Peter Michael Kragh, Jacob Giehm Mikkelsen, Erling Falk, Lars Axel Bolund, Thomas Juhl Corydon
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The present invention relates to a genetically modified pig as a model for studying atherosclerosis. The modified pig model displays one or more phenotypes associated with atherosclerosis. Disclosed is also a modified pig comprising a mutation in the endogenous ApoE gene or part thereof and/or LDL gene or part thereof, and/or LDL receptor gene, and/or transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of atherosclerosis; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from atherosclerosis are disclosed.
A genetically modified pig as a model for studying atherosclerosis, wherein the modified pig expresses at least one phenotype associated with atherosclerosis, and/or
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A genetically modified pig as a model for studying atherosclerosis, the modified pig expressing at least one phenotype associated with atherosclerosis;
Dependencies are inferred from the claim text.