Transgenic Mice and Use Thereof as an Experimental Model
OwnerYu-Chun Lone, Anthony Pajot +1inventors
InventorsYu-Chun Lone, Anthony Pajot, François Lemonnier
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Abstract
The invention relates to the use of an expression vector construction coding for the functional HLA-DPal03β401 complex specifically identified by anti-HLA-DP antibodies, in order to create transgenic mice. The invention also relates to the use of the transgenic mice obtained, such as for the comparative preclinical study of the efficacy of vaccine candidates in order to asses the risks associated with the unwanted induction of an autoimmune disease and in order to determine a therapeutic strategy.
Claims13
The use, for creating transgenic mice, of an expression vector construct encoding the functional HLA-DPα103β401 complex, specifically recognized by anti-HLA-DP antibodies, characterized in that the construct comprises murine promoters of the IAβ and IAα genes associating the cDNAs encoding DPα103 and DPβ401.
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