US 2010/0138197 A1Published application

Device for Predicting and Managing Blood Glucose by Analyzing the Effect of, and Controlling, Pharmacodynamic Insulin Equivalents

OwnerPhilip Michael Sherinventor

Life of this patent

Estimating the term…

Abstract

Embodiments of the invention are devices for assisting users in the management of blood glucose concentration levels in patients. Devices of the invention provide users with detailed information related to the pharmacodynamic behavior of insulin in a patient. By displaying and accepting information concerning time-dependent rates and amounts of pharmacodynamic insulin unit equivalents, the devices of the invention empower the user to make effective decisions regarding insulin dosing.

Claims25

Dependent claims

A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;
a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;
a means for inputting insulin time-action profile data;
a means for inputting patient RBGC/I data, the responsiveness of the patient's blood glucose concentration to insulin, optionally as a function of time of day;
a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of:
d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
a microprocessor connected to the input means;
the microprocessor connected to a digital memory;
the microprocessor connected to wired or wireless communication means;
the microprocessor configured to perform calculations based upon inputted recent past blood glucose concentration data;
inputted insulin delivery data;
inputted insulin time-action profile data;
inputted patient RBGC/I data;
at least one of:
inputted d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
inputted
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
the microprocessor configured to calculate an item selected from the group consisting of:
d(PDIUE)/dt, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
,
an amount of pharmacodynamic insulin unit equivalent expenditure between times t1a and t2a, where t1a precedes t2a;
the microprocessor optionally configured to calculate
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
,
insulin on board (IOB), where tc is the current time and t∞ represents a future time when the pharmacodynamic effect of delivered insulin is exhausted;
the microprocessor configured to calculate blood glucose concentration;
a display connected to the microprocessor;
for displaying at least one of;
d(PDIUE)/dt;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
;
optionally displaying
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
;
and
displaying blood glucose concentration.

175 more elements

A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;
a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;
a means for inputting insulin time-action profile data;
a means for inputting patient RBGC/I data, the responsiveness of the patient's blood glucose concentration to insulin, optionally as a function of time of day;
a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of:
d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times hand t2, where t1 precedes t2;
a microprocessor connected to the input means;
the microprocessor connected to a digital memory;
the microprocessor connected to wired or wireless communication means;
the microprocessor configured to perform calculations based upon inputted recent past blood glucose concentration data;
inputted insulin delivery data;
inputted insulin time-action profile data;
inputted patient RBGC/I data;
at least one of:
inputted d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
inputted
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
the microprocessor configured to calculate an item selected from the group consisting of:
d(PDIUE)/dt, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
,
an amount of pharmacodynamic insulin unit equivalent expenditure between times t1a and t2a, where t1a precedes t2a;
the microprocessor optionally configured to calculate
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
,
insulin on board (IOB), where tc is the current time and t∞ represents a future time when the pharmacodynamic effect of delivered insulin is exhausted;
a display connected to the microprocessor;
for displaying at least one of;
d(PDIUE)/dt;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
,
optionally displaying
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
.

172 more elements

A device for managing blood glucose concentration comprising:

a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;
a means for inputting insulin time-action profile data;
a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of:
d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
a microprocessor connected to the input means;
the microprocessor connected to a digital memory;
the microprocessor connected to wired or wireless communication means;
the microprocessor configured to perform calculations based upon inputted insulin delivery data;
inputted insulin time-action profile data;
at least one of:
inputted d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
inputted
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
the microprocessor configured to calculate an item selected from the group consisting of:
d(PDIUE)/dt, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
,
an amount of pharmacodynamic insulin unit equivalent expenditure between times t1a and t2a, where t1a precedes t2a;
the microprocessor optionally configured to calculate
∫
tc
t


∞

[

(
PDIUE
)
/

t
]


t
,
insulin on board (IOB), where tc is the current time and ta, represents a future time when the pharmacodynamic effect of delivered insulin is exhausted;
a display connected to the microprocessor;
for displaying at least one of
d(PDIUE)/dt;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
;
optionally displaying
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
.

165 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/063,665Filed 1 Nov 2007
Priority: 1 Nov 2006
Published: 3 Jun 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

G16H 50/50
ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or…: for…
G16H 20/17
Relating to drugs or medications, e.g. for ensuring correct administration to patients: delivered via infusion or injection
A61B 5/14532
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
G16H 15/00
Ict specially adapted for medical reports

Family

Application60/855,878Us provisional application · filed 1 Nov 2006
US 8,204,729 B2Related patent
US 2010/0138197 A1This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…

Abstract

A device for managing blood glucose concentration comprising:

a means for inputting at least two recent past blood glucose concentration data items, each data item comprising a blood glucose concentration value and a time-of-measurement value;
a means for inputting insulin delivery data items, each data item comprising an insulin dosage amount and a time-of-delivery value;
a means for inputting insulin time-action profile data;
a means for inputting patient RBGC/I data, the responsiveness of the patient's blood glucose concentration to insulin, optionally as a function of time of day;
a means for inputting phamacodynamic insulin unit equivalent expenditure data, the data selected from the group consisting of:
d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
a microprocessor connected to the input means;
the microprocessor connected to a digital memory;
the microprocessor connected to wired or wireless communication means;
the microprocessor configured to perform calculations based upon inputted recent past blood glucose concentration data;
inputted insulin delivery data;
inputted insulin time-action profile data;
inputted patient RBGC/I data;
at least one of:
inputted d(PDIUE)/dt data, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
inputted
∫
t


1
t


2

[

(
PDIUE
)
/

t
]


t
data, an amount of pharmacodynamic insulin unit equivalent expenditure between times t1 and t2, where t1 precedes t2;
the microprocessor configured to calculate an item selected from the group consisting of:
d(PDIUE)/dt, a rate of pharmacodynamic insulin unit equivalent expenditure;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
,
an amount of pharmacodynamic insulin unit equivalent expenditure between times t1a and t2a, where t1a precedes t2a;
the microprocessor optionally configured to calculate
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
,
insulin on board (IOB), where tc is the current time and t∞ represents a future time when the pharmacodynamic effect of delivered insulin is exhausted;
the microprocessor configured to calculate blood glucose concentration;
a display connected to the microprocessor;
for displaying at least one of;
d(PDIUE)/dt;
and
∫
t


1

a
t


2

a

[

(
PDIUE
)
/

t
]


t
;
optionally displaying
∫
t


c
t


∞

[

(
PDIUE
)
/

t
]


t
;
and
displaying blood glucose concentration.

175 more elements

Facts

Application

12/063,665Filed 1 Nov 2007

Priority

1 Nov 2006

Published

3 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

G16H 50/50
ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or…: for…
G16H 20/17
Relating to drugs or medications, e.g. for ensuring correct administration to patients: delivered via infusion or injection
A61B 5/14532
Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g.…: for…
G16H 15/00
Ict specially adapted for medical reports