Radical scavenger and active oxygen eliminating agent
AssigneeInbiotex Inc.
InventorsShunji Natori, Kunimiki Ootsu, Hajime Okuyama
Life of this patent
Estimating the term…
Abstract
It is an object to provide a radical scavenger, an active oxygen-scavenging agent and the like, which are highly efficacious clinically and novel, and so as to attain the object, 3,4-dihydroxyphenylalanine derivatives such as N-β-alanyl-5-S-glutathionyl-1-3,4-dihydroxyphenylalanine (5-S-GAD) or pharmaceutically acceptable salts thereof are contained as an active ingredient.
Claims12
A radical scavenger containing a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R1 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R3 represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
An active oxygen-scavenging agent containing a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R1 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R3 represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
An antioxidant agent containing a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R1 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R3 represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
An agent for preventing and therapeutically treating diseases or symptoms due to free radicals or active oxygen, which contains a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R1 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
An ophthalmologic pharmaceutical composition containing a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R4 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R3 represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
A composition for organ storage or organ perfusion containing a 3,4-dihydroxyphenylalanine derivative represented by the following formula (I):
- [in the formula, R1 represents hydrogen atom or an appropriate amino acid residue;
- R2 represents hydrogen atom or a group represented by the following formula (II):
- [in the formula, R3 represents hydrogen atom or an appropriate amino acid residue;
- R4 represents hydroxyl group or an appropriate amino acid residue;
- and n represents 1 or 2];
- when either one of R1 and R2 is hydrogen atom, herein, the remaining one is never hydrogen atom],
- or a pharmaceutically acceptable salt thereof as an active ingredient.
Dependencies are inferred from the claim text.