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US 2010/0137628 A1Published application
Process for the synthesis of (methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine
AssigneeLes Laboratoires Servier
InventorsThierry Dubuffet, Jean-Pierre Lecouve, Jean-Paul Hermet
Life of this patent
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Abstract
Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.
Claims6
1-5. (canceled)
A process for the synthesis of a compound of formula (I)
- wherein 7-methoxy-1-naphthoic acid of formula (III):
- is subjected to the action of a reducing agent to yield the compound of formula (IV):
- the OH function of which compound of formula (IV) is converted into a leaving group and which is reacted with a cyanation reagent to yield the compound of formula (I), which is isolated in the form of a solid.
Dependencies are inferred from the claim text.