US 2010/0137577 A1 · ADENOSINE DERIVATIVES, METHOD FOR THE SYNTHESIS THEREOF, AND THE PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE INFLAMMATORY DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient

AssigneesFM Therapeutics Co., Ltd., The United States of America, AS Represented By the Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health

InventorsLak Shin Jeong, Hea Ok Kim, Kenneth A. Jacobson, Seung Ah Choe

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Abstract

Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A3 adenosine receptors and act as A3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

Claims20

Dependent claims

An adenosine derivative, represented by the following Chemical formula 1, or a pharmaceutically acceptable salt thereof:

wherein,
A is O or S,
R is a linear or branched C1˜C5 alkyl which is non-substituted or is independently or selectively substituted with one or more C6˜C10 aryl groups, a benzyl which is non-substituted or is independently or selectively substituted with halogen or one or more linear or branched C1˜C4 alkoxy groups, or a hydroxycarbonyl-substituted benzyl;
and
Y is H or a halogen atom.

2 more elements

Dependencies are inferred from the claim text.