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US 2010/0137575 A1Published application
Universal biological sample processing
OwnerD. Michael Connolly, Vera Tannous +2inventors
InventorsD. Michael Connolly, Vera Tannous, Richard S. Murante, Charles DeBoer
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Abstract
A method for preparing a sample by utilizing a mechanical force in the presence of a size stabilizer to break apart the sample to obtain nucleic acid molecules in a usable size range.
Claims20
A method for extracting nucleic acid fragments comprising the steps of:
- providing a biological sample;
- suspending said biological sample in a suspension solution comprising a size stabilizer;
- applying a mechanical force to said biological sample to extract nucleic acid molecules;
- the application of said mechanical force in the presence of said size stabilizer results in said nucleic acid molecules being reduced to a median fragment size having a median number of base pairs, wherein at least 60% of said nucleic acid molecules have a number of base pairs that are within 50% of said median number of base pairs.
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Dependencies are inferred from the claim text.