Oligopeptides and their use in cosmetics
AssigneeCognis France S.A.
InventorsPhilippe Moussou, Louis Danoux, Gilles Pauly, Jean-Luc Contet-Audonneau
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Abstract
The present invention relates to the cosmetic use of oligopeptides, cosmetic preparations which comprise such oligopeptides as well as certain oligopeptide derivatives themselves.
Claims10
Cosmetic use of oligopeptides with the structure of formula (I)
- R1-[AA]n-R2 (I)
- wherein [AA] comprises at least 4 consecutive amino acids, which are identical compared to 4 consecutive amino acids of SEQ ID No. 1 and/or wherein [AA] comprises at least 6 amino acids, of which 4, preferably 5, more preferably 6 are identical compared to 6 consecutive amino acids of SEQ ID No. 1
- wherein n=4 to 15
- wherein R1 is linked to the NH2-group of the amino-terminal part of [AA] and is chosen from the group consisting of
- d) —H,
- e) is a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which may be functionalised by a —OH, —SH, —COOH or —CONH2 group, or
- f) a sterol or a sphingolipid group which is joined to the amino terminal part of [AA] via a bifunctional linker
- wherein R2 is linked to the C═O group of the carboxy terminal part of [AA] and is chosen from the group which is formed from
- a) —OH,
- b) —NH2
- c) is a linear saturated or unsaturated or branched saturated or unsaturated alkoxy group having 1 to 24 carbon atoms, which may be functionalised by a
- —OH, —SH, —COOH or CONH2 group, or
- d) a sterol or a sphingolipid group.
Use according to any preceding claim, wherein [AA] comprises at most 14, preferably at most 10, more preferably at most 8, preferably at most 7, preferably at most 6, preferably at most 5 consecutive amino acids identical to respective amino acids of the amino acid sequence of SEQ ID No. 1, preferably to the amino acids no 1 to 15 of SEQ ID No. 1.
Use according to any preceding claim, wherein [AA] consists of at most 15, preferably at most 10, more preferably at most 8, preferably at most 7, preferably at most 6, preferably at most 5 consecutive amino acids identical to respective amino acids of the amino acid sequence of SEQ ID No. 1, preferably to the amino acids no 1 to 15 of SEQ ID No. 1.
Use according to any preceding claim, wherein [AA] comprises at least 4 consecutive amino acids of identical to amino acids no. 1 to 15 of SEQ ID No. 1 and/or wherein [AA] comprises at least 6 amino acids, of which 4, preferably 5, preferably 6 are identical compared to 6 consecutive amino acids of amino acids no.1 to 15 of SEQ ID No. 1, preferably to the amino acids no 1 to 15 of SEQ ID No. 1.
Use according to any preceding claim, characterized in that R1=H or a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 12 carbon atoms, preferably acetyl.
Use according to any preceding claims, characterized in that the oligopeptides are used in a concentration of from 0.05 to 500 ppm.
Oligopeptides with the structure of formula (I)
- R1-[AA]n-R2 (I)
- wherein [AA] comprises at least 4 consecutive amino acids, which are identical compared to 4 consecutive amino acids of SEQ ID No. 1 and/or wherein [AA] comprises at least 6 amino acids, of which 4, preferably 5, more preferably 6 are identical compared to 6 consecutive amino acids of SEQ ID No. 1
- wherein n=4 to 15
- wherein R1 is linked to the NH2-group of the amino-terminal part of [AA] and is chosen from the group consisting of
- i. —H,
- ii. a linear saturated or unsaturated or branched saturated or unsaturated acyl group having 1 to 24 carbon atoms, which may be functionalised by a —OH, —SH, —COOH or —CONH2 group, or
- iii. a sterol or a sphingolipid group which is joined to the amino terminal part of [AA] via a bifunctional linker
- wherein R2 is linked to the C═O group of the carboxy terminal part of [AA] and is chosen from the group which is formed from
- a) —OH,
- b) —NH2
- c) is a linear saturated or unsaturated or branched saturated or unsaturated alkoxy group having 1 to 24 carbon atoms, which may be functionalised by a —OH, —SH, —COOH or —CONH2 group, or
- d) a sterol or a sphingolipid group.
- with the proviso that if R1 is —H, R2 is not —OH;
- or that if R2 is —OH, R1 is not —H;
- and
- with the proviso that if R1 is —H, R2 is chosen form the group which is formed from
- b) —NH2
- c) -a linear saturated or unsaturated or branched saturated or unsaturated alkoxy group having 2 to 24 carbon atoms, or
- d) a sterol or a sphingolipid group.
Oligopeptides according to any preceeding claim which are able to stimulate the growth of human keratinocytes in-vitro.
Dependencies are inferred from the claim text.