Manufacturing Process Of Making Polymeric Amine Salts
AssigneeNavinta LLC
InventorsChristopher N. Jobdevairakkam, Hero Velladurai
Life of this patent
Estimating the term…
Abstract
A novel process of manufacturing sevelamer carbonate from a polyallylamine carbonate or bicarbonate chloride salt. Process for manufacture of carbonate and/or bicarbonate salts of water insoluble polymers containing amino groups that are useful as anion binders in the gastrointestinal (GI) system. The process arranges the polyallylamine chain in a solution in such a way that the cross-linking reaction with epichlorohydrin can be controlled at a desired reaction rate.
Claims34
A process of making cross-linked Polyallylamine carbonate salt comprising:
- (a) reacting homopolymer of polyallylamine hydrochloride with carbonate and/or bicarbonate ions to form polyallylamine chloride, carbonate and/or bicarbonate salt;
- (b) cross-linking the polyallylamine chloride, carbonate and/or bicarbonate salt obtained in step (a) with a cross-linking agent, in the presence of sodium hydroxide to form a wet gel;
- (c) reducing the particle size of the wet gel obtained in step (b);
- (d) purifying the wet gel particles obtained in the step (c) with water to significantly remove the ionic impurities;
- and
- (e) drying the purified gel particles obtained in step (d).
A process of making alkylated cross-linked Polyallylamine carbonate salt comprising:
- (a) reacting homopolymer of polyallylamine hydrochloride with carbonate and/or bicarbonate ions to form polyallylamine chloride, carbonate and/or bicarbonate salt;
- (b) cross-linking and reacting the polyallylamine chloride, carbonate and/or bicarbonate salt obtained in step (a) with a cross-linking agent and alkylating agents in the presence of sodium hydroxide to form a wet gel;
- (c) reducing the particle size of the wet gel obtained in step (b);
- (d) purifying the wet gel particles obtained in step (c) with water to significantly remove the chloride and/or bromide ions;
- and
- (e) drying the purified gel particles obtained in step (d).
A process of making colestipol carbonate and/or bicarbonate salt comprising:
- (a) reacting diethylene triamine hydrochloride with carbonate and/or bicarbonate ions to form diethylene triamine chloride, carbonate and/or bicarbonate salt;
- (b) reacting and copolymerizing the diethylene triamine chloride, carbonate and/or bicarbonate salt obtained in step (a) with a copolymerizing agent, in the presence of sodium hydroxide to form a wet gel;
- (c) reducing the particle size of the wet gel obtained in step (b);
- (d) purifying the wet gel particles obtained in step (c) with water to significantly remove the chloride ions;
- and
- (e) drying the purified gel particles obtained in step (d).
Dependencies are inferred from the claim text.