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US 2010/0137512 A1Published application
Polyethylene glycol/polycation block copolymers
AssigneeThe University of Tokyo
InventorsKazunori Kataoka, Naoki Kanayama, Keiji Itaka, Shigeto Fukushima, Atsushi Harada
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Abstract
The invention provides block copolymers formed of poly(ethylene glycol) segments and poly(amino acid derivative) segments having side chains of at least one kind of specific amine residue. The invention also provides polyion complexes of such copolymers with polynucleotides and the like. These block copolymers are useful as carriers for in vivo delivery of active substances such as DNA.
Claims11
1-13. (canceled)
A polyethylene glycol/polycation block copolymer represented by formula (II) or a salt thereof,
- in which R1 stands for hydrogen, or a substituted or unsubstituted, straight or branched chain C1-12 alkyl,
- L2 stands for a linker,
- R2 stands for methylene or ethylene,
- R4 is either the same as R5 or the formula —NH—R9, wherein R9 is unsubstituted or substituted straight or branched chain C1-20 alkyl,
- R5s each independently stands for hydroxyl, oxybenzyl or —NH—(CH2)a—X group, wherein X each independently stands for an amine containing one, two or more members of the group consisting of primary, secondary and tertiary amines and quaternary ammonium salt, with the proviso that at least 85% of R5s are —NH—(CH2)a—X,
- a is an integer of 1-5,
- m is an integer of 5-20,000,
- n is an integer of 2-5,000 and
- x is an integer of 0-5,000, with a proviso that x is not greater than n.
6 more elements
Dependencies are inferred from the claim text.