Ibuprofen for Topical Administration
AssigneeBioChemics, Inc.
InventorsStephen G. Carter, Zhen Zhu, Kanu Patel, Diane L. Kozwich
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Abstract
Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl)propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.
Claims27
A composition comprising:
- a) the free acid form of 2-(4-isobutylphenyl)propionic acid;
- b) a pharmaceutically acceptable solvent;
- and
- c) at least one excipient.
A method of preparing an a pharmacological composition the method comprising:
- a) solubilizing ibuprofen in a pharmaceutically acceptable solvent;
- b) creating an active drug containing solution by combining the solubilized ibuprofen with a skin conditioner and a preservative;
- c) creating an aqueous solution containing a conditioner, a pH stabilizer and a preservative;
- d) creating an emollient phase by combining an emulsifier, a preservative, an oil and a stabilizer;
- e) combining and homogenizing the emollient phase and the aqueous solution to create a homogenized mixture;
- and
- f) adding the active drug containing solution to the homogenized mixture under temperature conditions avoiding degradation of the ibuprofen.
Dependencies are inferred from the claim text.