Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer
AssigneeThe Johns Hopkins University
InventorsJean-Francois Geschwind, Mustafa Vali
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Abstract
The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to pH of 2 and less than or equal to a pH of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.
Claims31
A method of treating cancer in a subject comprising administering to the subject an effective amount of a pharmaceutical composition comprising a pharmaceutical agent represented by the general formula:
- wherein, independently of each occurrence:
- X represents a halide, a sulfonate, a carboxylate, an alkoxide, or an amine oxide;
- R1 represents OR, H, N(R″)2, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, or C6-C12 heteroaryl;
- R″ represents H, C1-C6 alkyl, or C6-C12 aryl;
- R represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′;
- and
- R′ represents H, C1-C20 alkyl or C6-C12 aryl;
- and wherein the pharmaceutical composition has an acidity of greater than or equal to about pH 2 and less than or equal to about pH 6.
A pharmaceutical composition comprising a pharmaceutical agent represented in the general formula:
- wherein, independently of each occurrence:
- X represents a halide, a sulfonate, a carboxylate, an alkoxide, or an amine oxide;
- R1 represents OR, H, N(R″)2, C1-C6 alkyl, C6-C12 aryl, C1-C6 heteroalkyl, or C6-C12 heteroaryl;
- R″ represents H, C1-C6 alkyl, or C6-C12 aryl;
- R represents H, alkali metal, C1-C6 alkyl, C6-C12 aryl or C(O)R′;
- and
- R′ represents H, C1-C20 alkyl or C6-C12 aryl;
- and wherein the pharmaceutical composition has an acidity of greater than or equal to about pH 2 and less than or equal to about pH 6.
Dependencies are inferred from the claim text.