Method for treating atherosclerosis or restenosis using microtubule stabilizing agent
AssigneeThe Govt. of the U.S.A. as represented by the Secretary of the Dept. of Health & Human Services
InventorsJames L. Kinsella, Steven J. Sollott
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Abstract
The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefore. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabilizing agent such as taxol or a water soluble taxol derivative. The low dose used in the present invention prevents artery blockage while minimizing any negative side effects associated with the drug.
Claims4
A method of inhibiting or reducing restenosis or atherosclerosis in a patient comprising:
- infusing a patient with a pharmaceutical preparation comprising a therapeutically effective amount of taxol or a taxol derivative, wherein the pharmaceutical preparation is in-line filtered during infusion.
A method of inhibiting or reducing restenosis or atherosclerosis in a patient comprising:
- administering to the patient about 0.5 to about 2 mg/kg of taxol or a taxol derivative over about a 24 hour time period prior to vascular surgery;
- administering to the patient about 0.25 to about 2 mg/kg of taxol or a taxol derivative over about a 24 hour time period after the vascular surgery;
- and then
- administering to the patient about 0.25 to about 2 mg/kg of taxol or a taxol derivative over about a 24 hour time period every 21 days for 1 to 6 cycles.
Dependencies are inferred from the claim text.