Cadherin-11-mediated modulation of hair growth
OwnerAngela M. Christianoinventor
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Abstract
The present invention provides for methods of inhibiting hair growth, comprising decreasing the level of CAD1 1 mRNA and/or protein in hair follicle cells of a subject. The present invention further provides for methods of promoting hair growth, comprising increasing the level of CADI 1 mKNA and/or protein in hair follicle cells of a subject. The invention also provides for transgenic animals with aberrancies in CADI 1 expression, and for assay systems (including transgenic animals and cell-based systems) that may be used to identify agents that decrease or increase CADI 1 expression.
Claims7
-54. (canceled)
A method for promoting hair growth comprising administering an agent to a subject, wherein the administered agent elicits an increase in the level of a cadherin-11 (CAD11) in a cell, and wherein the agent is a nucleic acid comprising a nucleic acid having a sequence selected from the group consisting of SEQ ID NO:5, a sequence at least 90 percent homologous to SEQ ID NO:5, and a nucleic acid sequence that encodes a protein having amino acid sequence SEQ ID NO:2.
(canceled)
Dependencies are inferred from the claim text.