Compositions and Methods for the Treatment of Diseases Associated with Aberrant Cilia Assembly and Regulation
OwnerOlga V. Plotnikova, Elena N. Pugacheva +1inventors
InventorsOlga V. Plotnikova, Elena N. Pugacheva, Erica A. Golemis
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Abstract
Compositions and methods are provided for identifying agents which have efficacy for the treatment of disorders related to aberrant cilial structure and function, including polycystic kidney disease.
Claims10
A method for identifying agents which modulate calmodulin-Aurora A complex formation having efficacy for the treatment of polycystic kidney disease (PKD), comprising:
- a) providing kidney cells which express Aurora A and calmodulin and incubating cells in the presence and absence of said agent and in the presence of a molecule which induces release of Ca2+;
- b) determining the extent said agent disrupts calmodulin-Aurora A complex formation following release of calcium, agents which disrupt complex formation having efficacy for the treatment of PKD.
A method for inhibiting progression of polycystic kidney disease in a patient in need thereof, comprising administration of an effective amount of an aurora kinase inhibitor, said inhibitor being effective to inhibit cyst formation in the kidney.
Dependencies are inferred from the claim text.