Preventive and/or therapeutic agent for urine collection disorder accompanying lower urinary tract obstruction

Abstract

An agent for the treatment of urine collection disorders associated with lower urinary tract obstructive disease, characterized by containing an indoline derivative represented by the following general formula (I): wherein R represents optionally substituted aliphatic acyl optionally having an unsaturated bond, hydroxyalkyl, aliphatic acyloxyalkyl, lower alkoxy, carboxy, lower alkoxycarbonyl, aryl(lower alkoxy)carbonyl, carbamoyl, (mono- or dialkyl)carbonyl or cyano(lower alkyl), optionally halogenated aromatic acyl, furoyl, or pyridylcarbonyl; R1 represents cyano or carbamoyl; and R2 represents lower alkyl optionally having a halogen atom, cyano group, or aryl group, or a pharmaceutically acceptable salt of the derivative. The derivative and salt are usable as an agent for the treatment of urine collection disorders associated with lower urinary tract obstructive disease.

Dependencies are inferred from the claim text.