Pyrazole inhibitors of wnt signaling

A method for treating a disease or condition associated with Wnt pathway signaling in a mammal, comprising administering to said mammal an effective amount of a compound of formula I:

• wherein
• R1 to R5 are independently H, halogen, hydroxyl, carboxyl, amino, alkyl, alkoxy, aryloxy, acyl, a carbocycle or a heterocycle;
• wherein said carbocycle and heterocycle are optionally substituted with hydroxyl, halogen, alkyl, sulfonyl and alkoxy;
• and said alkyl, alkoxy and acyl group is optionally substituted with hydroxyl, halogen, amino, nitro, cyano, carboxyl, sulfonyl, a carbocycle or a heterocycle;
• and
• R6 is H, halogen, hydroxyl, alkyl, haloalkyl, alkoxy or acyl;
• or R6 is a covalent bond to R9;
• R7 is OH or —X;
• X is —NH—Y, —NR8—Y, —NR8—C(O)—Y, —NR8—C(O)—O—Y, —NR8—C(O)—NR8—Y, —NR8—S(O)2—Y, —NR8—C(NH)—NR8—Y, or —N═C(R9)—NR8—Y wherein R9 is H or alkyl, and R9 is divalent O or S covalently bonded to R6;
• Y is H, cyano, alkyl, a carbocycle or a heterocyle;
• wherein said alkyl is optionally substituted with halogen, hydroxyl, alkoxy, amino, nitro, cyano, carboxyl, sulfonyl, a carbocycle or a heterocycle wherein said carbocycles and heterocycles are optionally substituted with hydroxyl, halogen, alkyl or haloalkyl;
• and
• Z is —NR8— or —CR10R11— wherein R10 and R11 are independently alkyl or halogen.

A method for treating cancer comprising administering to a mammal in need thereof an effective amount of a compound of formula I:

• wherein
• R1 to R5 are independently H, halogen, hydroxyl, carboxyl, amino, alkyl, alkoxy, aryloxy, acyl, a carbocycle or a heterocycle;
• wherein said carbocycle and heterocycle are optionally substituted with hydroxyl, halogen, alkyl, sulfonyl and alkoxy;
• and said alkyl, alkoxy and acyl group is optionally substituted with hydroxyl, halogen, amino, nitro, cyano, carboxyl, sulfonyl, a carbocycle or a heterocycle;
• and
• R6 is H, halogen, hydroxyl, alkyl, haloalkyl, alkoxy or acyl;
• or R6 is a covalent bond to R9;
• R7 is OH or —X;
• X is —NH—Y, —NR8—Y, —NR8—C(O)—Y, —NR8—C(O)—O—Y, —NR8—C(O)—NR8—Y, —NR8—S(O)2—Y, —NR8—C(NH)—NR8—Y, or —N═C(R9)—NR8—Y wherein R8 is H or alkyl, and R9 is divalent O or S covalently bonded to R6;
• Y is H, cyano, alkyl, a carbocycle or a heterocyle;
• wherein said alkyl is optionally substituted with halogen, hydroxyl, alkoxy, amino, nitro, cyano, carboxyl, sulfonyl, a carbocycle or a heterocycle wherein said carbocycles and heterocycles are optionally substituted with hydroxyl, halogen, alkyl or haloalkyl;
• and
• Z is —NR8— or —CR10R11— wherein R10 and R11 are independently alkyl or halogen.