Azaindole-indole coupled derivatives, preparation methods and uses thereof

An azaindole-indole coupled derivative represented by the formula (IG) or the pharmaceutically acceptable salts thereof:

• Y═Z (IG)
• wherein,
• Y is an azaindole group represented by formula (Y1) or (Y2);
• Z is an indole group represented by formula (Z1) or (Z2);
• “═” represents the double bond which is located between the 3-position of the azaindole group (Y) and the 2′- or 3′-position of the indole group (Z);
• in the above Y1, Y2, Z1 and Z2, R1 and R1′ independently represent H or the following groups which may be unsubstituted or substituted by 1 to 3 substituents:
• C1-C6 alkyl, aryl, aralkyl, acyl, aroyl, glycosyl or biosyl protected by acyl, glycosyl or biosyl;
• wherein said substituents are selected from:
• halogen, hydroxyl, C1-C3 alkyl, nitro or amino;
• R2, R3, R4, R2′, R3′, R4′ and R5′ independently represent H, halogen, hydroxyl, sulfhydryl, or the following groups which may be unsubstituted or substituted by 1 to 3 substituents:
• C1-C4 alkyl, nitro, amino, amido, amide, C1-C4 alkoxy, methylthio, phenyl, phenoxy, aryl, aralkyl, trifluoromethyl, acyl, aroyl, sulfonic group, sulfamoyl, isocyanate, or alkyl isocyanate;
• wherein said substituents are selected from:
• halogen, hydroxyl, C1-C3 alkyl having, nitro or amino;
• R represents oxygen, sulfur, selenium, or a NR6 or NOR6 group, wherein R6 is H, or the following groups which may be unsubstituted or substituted by 1 to 3 substituents:
• C1-C6 straight-chain or branched-chain alkyl, aryl, aralkyl, C3-C6 alicyclic group, acyl, aroyl, sulfonyl or phosphoryl;
• wherein said substituents are selected from:
• halogen, hydroxyl, C1-C3 alkyl, nitro or amino.