Substituted arylcyclopentenes as therapeutic agents

A compound of the formula

• or a pharmaceutically acceptable salt thereof;
• wherein a dashed line represents the presence or absence of a bond;
• Y is an organic acid functional group, or an amide or ester thereof comprising up to 14 carbon atoms;
• or Y is hydroxymethyl or an ether thereof comprising up to 14 carbon atoms;
• or Y is a tetrazolyl functional group;
• A is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O;
• or A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or C≡C—;
• U1 and U2 are independently H, O;
• OH, I, Br, Cl, F, CF3, CN, or CH2OH;
• J is
• U3 is H, OH, I, Br, Cl, F, CN, C1-6 alkyl, aryl, heteroaryl, or C1-6 hydroxyalkyl;
• and
• B is aryl or heteroaryl.

A compound of the formula

• or a pharmaceutically acceptable salt thereof;
• wherein a dashed line represents the presence or absence of a bond;
• Y is carboxylic acid or a bioisostere thereof;
• A is —(CH2)6—, cis —CH2CH═CH—(CH2)3—, or —CH2C≡C—(CH2)3—, wherein 1 or 2 carbon atoms may be replaced by S or O;
• or A is —(CH2)m—Ar—(CH2)o— wherein Ar is interarylene or heterointerarylene, the sum of m and o is 1, 2, 3, or 4, and wherein 1 —CH2— may be replaced by S or O, and 1 —CH2—CH2— may be replaced by —CH═CH— or C≡C—;
• U1 and U2 are independently H, O;
• OH, I, Br, Cl, F, CF3, CN, or CH2OH;
• J is
• U3 is H, OH, I, Br, Cl, F, CN, C1-6 alkyl, aryl, heteroaryl, or C1-6 hydroxyalkyl;
• and
• B is aryl or heteroaryl.